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To see if their findings in ferrets were relevant to COVID-19 patients, the researchers then measured blood IFN levels in a cohort of hospitalized patients who tested positive for SARS-CoV-2

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Thus, a functional overexpression of MnSOD, caused by presence of the Ala variant, combined with a potential deficiency of GPx-1, caused by the Leu variant, could potentially create a redox imbalance leading to enhanced hydrogen peroxide flux

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