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The RNA purification, reverse transcription, library construction, and sequencing were performed at Shanghai Biotechnology Corporation Co., Ltd

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Among them, UQCRB is one of the subunits of the mitochondrial respiratory chain complex III, and mutations in UQCRB increase mtROS production and activate HIF-1 transactivation, promoting vascular neovascularization, a process that can be regulated by UQCRB inhibitors (209)

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