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Interestingly, previous studies have shown the associations of ASD with polymorphisms in the genes of oxidative stress markers

[DOI] [PubMed] [Google Scholar] 62.Madesclaire M

doi: 10.3390/ijms21165895

Splenic nerve is required for cholinergic anti-inflammatory pathway control of TNF in endotoxemia

Under normal conditions, Kelch-like ECH associated protein 1 (Keap 1), which functions as an adaptor protein, is bound to Nrf2 and serves for Nrf2s continuous ubiquitylation and degradation, while under oxidative stress conditions, Keap 1 is inactivated resulting in the translocation of Nrf2 into the nucleus where the transcription of antioxidant genes begins (Baird et al