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Fikry H, Saleh LA, Abdel Gawad S

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It was discovered that Sdd3 negatively regulates the upstream activating factor Rho1 GTPase through direct interaction with the GTPase-activating protein Bem2 of Rho1, thereby significantly reducing the chitin content in the fungal cell wall and causing defects in biofilm formation

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Imbalanced mitochondrial Ca 2+ homeostasis not only exacerbates oxidative stress but also activates the unfolded protein response and pro-inflammatory signaling cascades, establishing a self-amplifying neurodegenerative loop 31