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Nutritional Deficiencies The mechanism that makes GLP-1 medications effective, slowing digestion and reducing food intake, can also lead to significant nutritional gaps: Many patients consume fewer calories, making it difficult to obtain adequate nutrients Altered digestive processes may reduce the efficiency of nutrient absorption Key nutrients at risk include calcium, vitamin D, B vitamins, iron, and protein 4

Sulfonation reactions are catalyzed by sulfotransferases (SULT) and involve the transfer of a sulfonate group (-SO3) from a cofactor (PAPS - 3'-phosphoadenosine-5'-phosphosulfate) onto a nucleophilic xenobiotic