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Description
A reduction or lack of gastric acid and pepsin diminishes the release of vitamin B 12 from food and hence decreases its availability for absorption in the ileum [93]
Quick Answer: Tirzepatide has no established direct effect on vitamin B12 levels, but indirect factors such as reduced dietary intake, slowed gastric emptying, and concurrent metformin use may increase deficiency risk

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Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function

Side effects of B12 deficiency can include decreased cognitive function, fatigue, lethargy, feeling faint, depression or irritability, headache, balance issues and more

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