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Glutathione seems to be well tolerated

Add in the stress of work, family life, and sleep that is not always great, and recovery becomes a real bottleneck

The subjects were kept in plastic enclosures with regulated humidity (55 1%), temperature (%), and a light-dark cycle of 12 h each

In addition, iron deficiency can promote neo-vascularization due to hypoxia-inducible factor 1a (HIF1a) expression and stabilization [80], as well as causing the production of mitochondrial ROS that enhances cancer cell invasion and migration [81]

doi:10.1007/s00441-019-03016-8 [2] Deek SA

This suggests that sesamin directly quenched ROS and alleviated oxidative burden, making an extreme upregulation of catalase unnecessary