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Tirzepatide is a dual GIP/GLP-1 receptor agonist administered as a weekly subcutaneous injection, producing up to 20.9% weight loss at 72 weeks in Phase 3 trials

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Chang C.H., Tsai W.C., Lin M.S., Hsu Y.H., Pang J.H.S

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Abu-Bip-CN was identified as the most potent inhibitor in the series (half-maximal inhibitory concentration [IC 50 ], 13 3 nM [pIC 50 , 8.7]) but was poorly potent in the cell assay due to rapid proteolytic withdrawal in the cell assay medium