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Description
In one study on the Shank3-deficient ASD mouse model, the chronic administration of OXT prevented social deficits after 2 weeks of treatment but led to social ambivalence beyond that

Our results suggest that some children with autism (those with low tryptophan and phenylalanine) would benefit from either increased protein intake, use of digestive enzymes containing proteases, and/or supplements of tryptophan (or 5-HTP) and phenylalanine
J Pharmacol Exp Ther 263:964970 Kannan R, Mittur A, Bao Y, Tsuruo T, Kaplowitz N (1999) GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter

Senafi SB, Clarke DJ, Burchell B

Excessive circulating lipids cause neuroinflammation and oxidative damage, both associated with cognitive impairment

Cell 187: 26012627, 2024
