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34 However, we cannot exclude the possibility that depletion and exhaustion of lymphocytes resulted from anti-inflammatory therapies such as the administration of glucocorticoids

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Clin Pharmacol Ther 103:971974 Hua Z, Liu L, Shen J, Cheng K, Liu A, Yang J, Wang L, Qu T, Yang H, Li Y (2016) Mesenchymal stem cells reversed morphine tolerance and opioid-induced hyperalgesia

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Driven by the need to estimate internal exposures where in vivo data generation is not possible, alternative testing strategies incorporating in vitro and in silico human specific models have recently gained interest