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doi: 10.1186/1475-2891-13-11 268

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Unlike chemical assays such as DPPH and ABTS, cellular modelsusing cell lines like Caco-2, HepG2, or SH-SY5Yconsider critical factors such as compound uptake, metabolism, and intracellular redox signaling, thereby yielding more physiologically meaningful data

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The activity of several involved enzymes also increase, including those that allow an influx of sulphur (as inorganic sulphate, that is converted into homocysteine as the entry step into biological organic species), which is the rate-limiting element for the biosynthesis of biological thiols [25,26]