glutathione gsh gssg Dysregulation of Homeostasis in Neurodegenerative Diseases and cysteine Reduced (GSH) and oxidized (GSSG)

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PM is known to broadly modify the hippocampal transcriptome, leading to the activation of several pathways functionally related to the major components of the physiopathology of this disease, including microglia activation, oxidative stress, BBB disruption, leukocyte extravasation into the CNS, neuroinflammation, and cell death, among others

The elevated antioxidant capacity driven by persistent NRF2 activation and enhanced glutathione (GSH) and thioredoxin (TRX) systems enables cancer cells to withstand endogenous oxidative stress and promotes metastatic behavior

[updated 2023 Dec 15

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