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Manufacturing advancements, including patented optimized production methods [167], support scalability toward GMP-compliant batches

MECP2 mutations account for most cases of typical forms of Rett syndrome

The trimethylamine degradation marker is routinely quantified at thresholds below 50 ppm per USP residual solvent guidelines

Dai C, Liu WX, Jiang M, Sun MJ

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Whilst it has a good safety profile, adverse effects of valproic acid in chronic use include hepatotoxicity ranging from transient elevation of liver enzymes to fulminant liver failure and hyperammonaemia with resultant encephalopathy