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Activation of IGF-1R results in the recruitment and phosphorylation of multiple adaptor proteins including insulin receptor substrates (IRSs) and Shc, leading to activation of two pro-survival signaling pathways

16 IRS-1/2 proteins serve as scaffolds to activate other intermediate signaling proteins such as PI3K/AKT/mTOR 17 and Ras/Raf/MAPK 18 and this function has been well-reported in all breast cancer subtypes

(Tokyo) 2020, 68 (3), 258264

Long-term smoking not only elevates the risk of lung cancer but is also closely associated with the incidence of hypertension

Multi-mycotoxin screening reveals the occurrence of 139 different secondary metabolites in feed and feed ingredients

Interactions between prolactin and kisspeptin to control reproduction