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Development 144 (22), 40474060

When such PD models are combined with the existing clinical data reviewed above that show improved UPDRS scores, one may surmise there would be a direct effect of ketone bodies to support a deficient but not yet degenerated population of dopaminergic neurons in the substantia nigra and their synaptic partners in the striatum

Similarly, the current American Urological Association and American Society for Reproductive Medicine guidelines question the benefits of AOXs in treating male infertility, and indicate lack of data to recommend the use of specific agents for this purpose (Moderate Recommendation

Resveratrol can stimulate the activity of Nrf2, upregulate a variety of antioxidant enzymes such as NQO1 and HO-1, and control -glutamylcysteine synthetase (GCLC), the enzyme that regulates glutathione synthesis [193]