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Key accelerators of this breakdown include: Neuroinflammation: Cytokines from Lyme, Long COVID, or concussion damage synaptic connections.[5] Mitochondrial dysfunction: Energy factories in cells fail, starving muscles and brain of ATP.[6] Disrupted proprioception: The body loses its internal GPS, leading to imbalance and falls.[7] Sympathetic overdrive: Chronic fight-or-flight traps patients in pain/fatigue cycles.[8] Muscle atrophy: Inactivity after injury or illness causes rapid loss of strength and stability.[9] These create a vicious feedback loop

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Work from the Granneman group identified ABHD5 ligands that could stimulate lipolysis by bypassing receptor activation through the dissociation of ABHD5 from PLIN1 (48)

B12 deficiency and methylation support protocols

doi: 10.1136/gut.42.1.2