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Additionally, many NRF2-regulated metabolic pathways were found to confer growth advantages to cancer cells, such as the upregulation of the PPP, nucleotide synthesis, and NADPH production

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Serine Serine, synthesized endogenously from glucose or absorbed from the extracellular environment, contributes to nucleotide synthesis, one-carbon metabolism, and cellular protection against oxidative stress through glutathione biosynthesis

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