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One study gave glutathione to patients with atherosclerosis and found that it significantly improved endothelial function by enhancing nitric oxide activity (8)

G.BogdanosD

However, its optimal usage strategy and long-term benefits still require further clarification in broader real-world settings

Miao L, Zhang J, Yin L, Pu Y

Based on the support from existing clinical, pathological, and experimental data, the mechanisms can be categorized into three classes: First, strong-evidence mechanisms fully validated by clinical and experimental studies include mitochondrial dysfunction and apoptosis

This was further supported by non-inferiority testing, which demonstrated that L-arginine was not clinically worse than glutamine in improving OHIP-14 scores, thereby validating its potential as an alternative therapy based on both clinical and patient-centered outcomes