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however, this phenomenon is accompanied by a continuous release of glutamate and substance P onto the second-order neurons, alongside diminished central levels of opioid peptides and serotonin [139,140]

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Neutrophils were stimulated with LPS (10 g ml 1 ), PMA (100 nM), A23187 (1.25 M) or crosslinking CD16 (2.4G2, 553142, BD) with a secondary goat anti-rat IgG (112-005-062, Jackson ImmunoResearch)

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