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Supporting information S1 Fig

Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease

Pryor WA, Dooley MM, Church DF

The regulation of the different roles of GSH and the precise mechanisms by which it acts as a signal transducer under metal-induced oxidative stress is currently under intense investigation and will provide essential information to understand the cellular responses to metal toxicity

however, studies have demonstrated the potential involvement of mitochondria, endoplasmic reticulum, -synuclein or dopamine levels in contributing to cellular oxidative stress as well as PD symptoms

Data are derived from 5 individual replicates with SD indicated