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Three treatment options were considered: observation, interventional thermo-ablation therapy, or liver Stereotactic Body Radiation Therapy (SBRT)

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2 ) A delayed killing induced by the end product, Cu-DDC ( via the disulphide bond breakage in the gastrointestinal system and the bloodstream of the portal vein ( Therefore, we hypothesised that using nano-drug-delivery system to protect the sulfhydryl groups in DDC will overcome the discrepancy between the anticancer activity of DSF in laboratory and clinic and pave the path between bench and bed. Based on this hypothesis, our group first encapsulated DSF into liposomes and demonstrated significantly improved anticancer efficacy in mouse models (Figure 4)