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Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts

Doses of 0.6 mL/d, administered three times a day for one month, and 1 mL/d, divided into three doses over two months, were assessed for their impact on haemoglobin, blood counts, liver and kidney functions, bleeding and clotting time and serum electrolytes

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The leap from animal model findings to confirmed human benefit is significant, and many compounds that show promise in preclinical research do not translate successfully to human medicine