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Reynolds and colleagues then showed in a 2021 Nature Communications paper that MOTS-c improved running capacity in young, middle-aged, and older mice, which is why some clinic and community sources call it an exercise-mimetic

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Stress and Hormone Modulation: Evidence suggests DSIP may regulate cortisol, growth hormone, and other neuroendocrine pathways, contributing to stress reduction and recovery

This is one possible mechanism behind the association between inflammation, chronic diseases such as cardiovascular and metabolic conditions, and mood and anxiety disorders