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The Johnson and Johnson vaccine is similar to AstraZeneca but uses a different adenovirus, adenovirus 26

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Activation of plaque macrophages by other immune cells through CD40TRAF6 signaling triggers NF-B activation, amplifies pro-inflammatory cytokine secretion, promotes macrophage polarization towards the M1 phenotype, and enhances immune cell recruitment, collectively contributing to the progression of atherosclerosis