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Hypoxia-inducible factor 1 (HIF-1) is a transcription factor characterized by a basic helix-loop-helix/Per-Arnt-Sim domain, which plays a key role in regulating cellular responses to oxygen deprivation and acts as a crucial driver in tumor angiogenesis [8]

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(128) vacuum cooling treatment and various storage conditions, including cold rooms and modified atmosphere packaging, affected antioxidant enzyme activity in Agaricus bisporus mushrooms, revealing that vacuum-cooled mushrooms exhibited enhanced activity of antioxidant enzymes like superoxide dismutase, catalase, peroxidase and polyphenoloxidase along with a reduction in malondialdehyde levels and the generation of superoxide anions