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[PubMed] [Google Scholar] Ritter C.A., Bohnenstengel F., Hofmann U., Kroemer H.K., Sperker B

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Using the BODIPY C11 assay, we observed that hypoxia increased lipid peroxidation in cultured proliferating and differentiating chondrocytes of both genotypes, but the most pronounced increase was observed in G6PDH-null differentiating hypoxic chondrocytes, which display the highest ROS levels (Extended Data Figs

Complement activation, cytotoxicity, and alterations in cell junction proteins (e.g., reduced connexin-43) may also exacerbate tissue injury(Wroska et al., 2024)