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The compound received FDA GRAS status for safety but was never approved as a drug because efficacy was insufficient for pharmaceutical registration

To date, no existing research has discovered any serious safety concerns with the use of GHK-Cu copper peptides

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Increasing levels of VitB12 in humans have been shown to lead to a decline in 24-h mean melatonin levels and nocturnal melatonin levels during bright-light exposure, thereby disrupting the sleep-wake cycle toward increased alertness and decreased sleep duration [21, 38]

The NHS recommends urgent assessment for rapidly progressive neurological symptoms

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