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I., & Reymert, M

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Beyond that date, you are in uncharted territory

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Not only is B12 non-toxic at such massive doses, but it actually helps clear the cyanide from the body

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A retrospective study looking at concomitant use of proton pump inhibitors (PPIs) alongside metformin in 614 people with type 2 diabetes in the US found a significant reduction in B12 levels of 34% in patients taking both medications, compared to controls taking either drug alone (Long et al, 2012)

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[11] [9] This explains why therapeutic doses are substantially higher than dietary requirements

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To prevent and manage obesity, bariatric surgery is often recommended to sustain weight loss [3]

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