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Each subunit is composed of two domains: a large N-terminal domain (residues 1 to 186) employing a Rossmann fold, and a smaller two-layered C-terminal domain (residues 187 to 290) with a helical layer on top of a three-stranded antiparallel -sheet

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Other groups have previously proposed a potential role of GluN2C/GluN2D subunits in schizophrenia 15,46,47

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Still, a few risks deserve attention: Absolute contraindications: Wilson's disease or any other copper metabolism disorder, active cancer (because of GHK-Cu's pro-angiogenic activity), pregnancy, and breastfeeding

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