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TR sumoylation may similarly impact metabolic genes directly regulated by TR and genes regulated by TR crosstalk with other nuclear receptors

As such, the split-dose L-carnitine protocol may offer a practical supplementation strategy for a broader athletic population seeking to optimize endurance capacity under high training loads

Evidence on common supplements mentioned by patients The authors of the study also provided a brief summary of research for some of the commonly mentioned supplements

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This synthetic carnitine derivative, chemically known as 3-(propanoyloxy)-4-(trimethylammonio)butanoate, functions as both an L-carnitine analogue and a propionate donor, supporting mitochondrial fatty acid oxidation while providing substrate for energy metabolism