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doi: 10.4103/jisp.jisp_54_17
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High-dose free curcumin exhibits dose-dependent hepatotoxicity, mechanistically arising from mitochondrial dysfunction, ROS overproduction, and activation of necroptosis pathways involving RIPK1/RIPK3 complexes in hepatic cells [74]

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two hydrogen-bonded helical configurations of the polypeptide chain

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