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Our findings highlight the pathological roles of endogenous DA in PD pathogenesis as well as LRRK2-PINK1 kinase pair and TH-DA pathway as a potential targets in future anti-PD therapies

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Immediately after fixation the samples were washed once briefly with MilliQ and stained overnight at 37C with fresh SA--GAL solution (pH 6.0), containing 2,5 mM Na2HPO4, 7,4 mM Citric Acid, 0.15M NaCl, 2mM MgCl2, 5 mM Potassium Ferricyanide, 5 mM Potassium Ferrocyanide and 25ul/ml 4% X-gal in DMF

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