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Robust Phase 2/3 studies are still lacking and most of the evidence remains preclinical
The secondary endpoints included collecting data on cognition, neuroimaging, and plasma and cerebrospinal fluid (CSF) biomarkers before and after treatment
[143] showed that Salmonella enterocolitis induced preferential damage to glutamatergic myenteric neurons expressing specific non-canonical inflammasome machinery and pointed to a neuroprotective role of ENS-associated tissue-resident macrophages mediated through an arginase 1-polyamine axis
The antimicrobial activities were comprehensively investigated (Table 3)
BPC-157 has been administered at doses ranging from 200 mcg to 1000 mcg/day in various regimens without consensus on therapeutic thresholds
