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Die sehr hohe Bindungsaffinitt der Streptavidin-Biotin-Interaktion (K D = 10 -15 ) wird bei einer Vielzahl von Anwendungen verwendet

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initially employed dithiol-appended substrates [Cys(Xaa) n Cys, where Xaa is arbitrary amino acids] to chemically crosslink AuNP aggregates for the colorimetric detection of thrombin, achieving a detection limit of less than 5 nM in 90 min
