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Under normal conditions, xCT shows no structural similarity to b 0,+ AT and is constitutively expressed only in certain organs such as the brain and the immune system

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10.1038/nature16937 17 FengH.YangY.ChenH.ZhangZ.ZengJ.HuangY.et al (2025)

[DOI] [PubMed] [Google Scholar] 203.Poljak, B

Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes

Although aberrant BDNF/TrkB signaling is implicated in several neurological, neurodegenerative and psychiatric disorders, neurotrophin-based therapy is challenging and is limited by improper pharmacokinetic properties of BDNF