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This process primarily facilitates the transcriptional priming signal necessary for inflammasome activation and does not directly induce the secretion of mature cytokines

Proc Natl Acad Sci USA 108:86748679 Cluntun AA, Lukey MJ, Cerione RA, Locasale JW (2017) Glutamine metabolism in cancer: understanding the heterogeneity

The research involved 72 patients with T2DM, out of which 41 received metformin at a dose of 1700 mg per day for at least 12 months, while 40 age- and sex-matched individuals served as control subjects

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