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Protective effect of methane-rich saline on acetic acid-induced ulcerative colitis via blocking the TLR4/NF-B/MAPK pathway and promoting IL-10/JAK1/STAT3-mediated anti-inflammatory response

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The inflammation can then further damage the intestinal epithelial cells and intracellular tight junctions

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Figure 1 Gross pathological changes expected in this disease model included increased lung mass, increased cellularity of the bronchoalveolar lavage fluid (BALF), epithelial thickening, and pockets of immune cell infiltrations in the lung parenchyma