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[129] also reported that high-dose vitamin D3 supplementation (100,000 IU every 2 months for 6 months) failed to improve vascular function markers or reduce fatigue in ME/CFS patients

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Ozkan S., Jindal S., Greenseid K., Shu J., Zeitlian G., Hickmon C., Pal L

2018;28:R17085

Int J Mol Sci (2020) 22:330

In the human body, L-carnitine is used to transport fatty acids into the cell's power plants (mitochondria), where they are "burned" into energy

This process is facilitated when tight junction dysfunction occurs or biological barriers are impaired, a phenomenon that is referred to as leaky gut concept [17]