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doi: 10.1146/annurev-pathmechdis-031521-041113 [DOI] [PMC free article] [PubMed] [Google Scholar] 23.Xu Y, Li Y, Yang X, et al

It functions as a redox-active peptide complex that interacts with copper-dependent enzymatic reactions

It is typically given as an injection every six months and has been shown to significantly reduce the risk of fractures in postmenopausal women with osteoporosis

Blood 102 , 33963403 (2003)

Even within the same family, disease manifestations can range from mild to severe

The timing and stability of these proteins are tightly controlled by post-translational mechanisms, including ubiquitin-mediated degradation