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In addition, curcumin treatment leads to cell cycle arrest at the S or G2/M phase in colon cancer (MC38 and HCT 116) cells, accompanied by a reduction in the protein expression of cell cycle-related markers (e.g., cyclin A2, cyclin E1, CDK2, and p21) [339, 340]

Conclusions MPs/NPs, as pervasive environmental contaminants, infiltrate humans through multiple exposure routes, traverse biological barriers, and accumulate in the central nervous systemconstituting a novel environmental hazard for PD pathogenesis

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