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In some GBM cells that harbor a methylated MGMT promoter, an alternative epigenetic mechanism activates a distal enhancer by promoting histone 3 lysine 27 acetylation (H3 K27ac) and overrides promoter methylation, driving MGMT expression and promoting TMZ resistance [103]
& Yang, H

The follow-up study has not been completed, so no results regarding elamipretides effectiveness for improving vision loss secondary to AMD are available. While the trial is still ongoing, there are a few takeaways worth noting

Vormann J, Goedecke T
