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Furthermore, the inhibition of DHODH also reduces the levels of vital antioxidants, such as GSH, which are necessary for counteracting lipid peroxides, thus rendering cells more prone to oxidative stress and lipid damage (173,174)

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The K d value of PGRMC1 binding to CYP51 was in a micromolar range and comparable with those of other haem proteins, such as cytochrome P450 reductase 35 and neuroglobin/ G i1 (ref