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As a precursor to key neurotransmitters like dopamine and norepinephrine, it helps maintain mental clarity and alertness during periods of physical exertion, fatigue, or high cognitive demand

49,51,52 In addition, imbalanced glutamate and GABA activity may contribute to a link between depression and chronic pain

Ethics declarations Ethics approval and consent to participate Manuscripts reporting studies involving human participants, human data, or human tissue must: The procedures and data collections in human study have been approved by Institutional Review Board of National Taiwan University Hospital (201507055MINC, 201712030RIND), and all participants signed a written informed consent form

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However, their 5.6 mg sublingual dose shows promise

(PubMed) Johnston CS, Luo B