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N.et al (2011)

10.1126/science.aad9948 11 DaiJ.WangW.HeF.YuX.LiuZ.WangY.et al (2025)

We then built the isobologram of the corresponding dose-response curves with a fixed dose ratio of R and compared the expected mixture of the two doses that produced an effect equal to half of the maximal effect produced by the individual drugs and to the experimental value (see later in methods)

Therefore, the researchers concluded that hydrogen might exert its neuroprotective effect through a ghrelin-independent pathway, potentially involving other compensatory mechanisms