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ChREBP mediates carbohydrate, but not fat-induced DNL as high fat diets do not activate ChREBP and may even decrease ChREBP activity [43, 47]

A lack of acid can be caused mainly by aging, stress, and acid suppressing medications

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revealed that the lysosomal inhibitor CQ promoted the binding of nuclear receptor coactivator 4 (NCOA4) to ferritin in MCF-7 cells and further mediated ferrinophagy, indicating the importance of NCOA4 in iron homeostasis and ferroptosis[68]

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