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The breakdown of alcohol enormously elevates the manufacturing of harmful free radicals which glutathione acts to neutralise

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These effects are dose-dependent and typically resolve within 48 weeks as GLP-1 receptor density downregulates in the gut

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( Epub 2024 May 16 )

The subsequent antigen presentation triggers the activation of Th1 and Th17 cells, leading to the release of pro-inflammatory cytokines (IL-2, TNF-, IFN-, IL-17), which in turn amplify oxidative stress and perpetuate an amplifying loop of inflammation and tissue damage (Kubiak et al