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DNMTi and HDACi can reactivate the transcription of these APM genes through demethylation or by promoting histone acetylation, restoring MHC-I expression on the tumor cell surface and enhancing their capacity to present antigens to CD8 + T cells [357]

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Shan X., Li J., Liu J., et al., Targeting Ferroptosis by Poly(acrylic) Acid Coated Mn(3)O(4) Nanoparticles Alleviates Acute Liver Injury, Nature Communications 14, no

Summary of the company update Umbrella Labs implemented documentation and process controls intended to improve clarity and reduce record fragmentation in laboratory workflows that use YK-11 as a recurring reference input

Some of these alkaloids have been approved by the FDA as chemotherapy drugs, such as camptothecin (CPT), 190 a well-known inhibitor of topoisomerase I, and vinblastine, 191 which interacts with microtubule proteins to cause mitotic disasters

Due to the low incorporation efficiency of ncAAs, the production yield of antibodies containing ncAAs is low, which limits the overall production of BsAbs