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The first mechanism is that ketones stimulate nuclear factor erythroid 2-related factor 2 (Nrf2) (14, 19, 122)

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Although earlier studies reported an incidence of 0.30.7%, recent publications have shown an overall incidence of 3.28.9%, with more than 75% of cases occurring in men between 45 and 65 years of age (1,2)

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