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Generally, ROS accumulation leads to DNA hypomethylation, as confirmed by different studies

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J Biol Chem 266 : 1005010053 Saito Y, Hayashi T, Tanaka A, Watanabe Y, Suzuki M, Saito E, Takahashi K 1999 Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase

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doi: 10.1002/(SICI)1097-4652(200002)182:2 3.0.CO;2-1

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