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40 Moreover, the inhibitory activities of these cyclic peptide inhibitors for NNMT were not affected by different concentrations of either NAM or SAM, suggesting that their interactions with NNMT were at an allosteric site other than the active site

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19 This ordered BiBi mechanism is indirectly supported by the 20-fold difference between MichaelisMenten parameters ( K m s) of SAM and NAM of 8.5 0.8 M and 199 32 M, respectively

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